Well, I ended up with a #145 main and a #58 pilot.
Here's the play-by-play, for the intake-through-exhaust story:
Bought the bike back in ~August 2017, got it running September or so. Intake was filthy, so scrapped the stock filter and adapted a large Uni pod filter to work in the stock airbox. Stock pipe, stock carb, stock jetting, stock ignition.
October 2017, read the "FT500 Essentials" and installed a #145 main and #58 pilot from ThumperStuff.
July 2018, installed the full Kerker system. Kept the #58 pilot, threw in a #165 main to see what happened. Saw that someone had already installed two shims under the needle. Off-throttle to mid-throttle there was noticeably more power. At WFO from about 3000 it blubbered, wouldn't rev out. I haven't jetted too many four-strokes, but it felt like it was eight-stroking.
A couple days later, got the Six Sigma jet kit. They recommended a #145 main, with a #140 or #150 option. They also recommended a #72 pilot jet (!), plus a couple shims under the needle. I installed the #150 and the #72 pilot, and kept the two shims under the needle. Started OK cold but died as soon as I choked it. The bike was pretty "fluffy" off-throttle and mid-throttle. At WFO it would pull up to redline (2nd, 3rd, 4th) but would still eight-stroke every now and then. Much improved WFO operation compared to the #165, but still not good.
Returned to the garage. Installed the #145 main and the #58 pilot. Less fluffy off-throttle, and revved out very cleanly (2nd, 3rd, 4th) at WFO.
I'll take it on a cruise this week or next, and peep the plug for a double-check.
Pretty happy!!! Hope the info above helps someone.